Endocrine Abstracts

Study question: Does the combination of estradiol valerate (EV) and dienogest (DNG) have favorable effects on inflammation and lipids compared with ethinyl estradiol (EE) + DNG?What is known already: Use of combined oral contraceptives (COCs) increases HDL-cholesterol and triglycerides and promotes low-grade inflammation. The metabolic effects of COCs depend on both estrogen and progestin components. To our knowledge this is the first study comparing COC...

Background: Combined oral contraceptives (COC) are known to have multiple beneficial effects besides contraception, but also cause some unwanted health outcomes. They interfere, for example, with metabolism, inflammation, hepatic protein synthesis and blood coagulation. COCs containing natural estrogens have recently been developed, yet little is known about their non-contraceptive effects compared to conventional COCs with ethinyl estradiol (EE). The aim of this study was to ...

Objective: To investigate comorbidity rate, symptoms, overall morbidity, medication useand use of health care services among women with polycystic ovary syndrome (PCOS).Design: Community-based prospective cohort study.Patients: Womenreporting oligo/amenorrhea and hirsutism at age 31 and/or PCOS diagnosis by age 46 (n = 280) and controls without PCOS related symptoms or diagnosis (n = 1573) in the Northern ...